Santander de Quilichao is best known in football circles as the birthplace of Adrián Ramos, but the city has produced 24 documented association football players in total. Other notable players include Luis Sinisterra, Helibelton Palacios, Kevin Balanta and José Moreno Mora. Among them are 23 male and 1 female players. Birth years range from 1961 to 2005.